LEFT: The classic Ares rocket configuration for Mars Direct missions.  Note that the ET is modified in these images with a cylindrical + hemispherical LOX tank and an aerodynamic  nose cone.  

RIGHT: Configuration for delivering 80 ton cargo modules to LEO.
LEFT: Module mounted on top contains all vital spaceship systems.  It's easier and safer to install all these on the ground and then launch the ship to LEO.  The LOX tank interior can be outfitted in LEO at the spaceship yards.  More ETs can be attached in space to make propellant tanks for increased reaction mass and delta V capacity.  NTR is already mounted at bottom of ET.
Configuration for launching two ETs, one filled with LH2 and LOX for propulsion to LEO and one empty.  Complete ET based ships and space station modules can also be launched in this config. The ETs are staggered for aerodynamic reasons.
LEFT: Space Shuttle Z with Gemini capsule and rocket stage to propell the two-man craft to GEO for satellite repair missions.
ARES configurations
RIGHT) Space
Shuttle stack and
CEV configuration.
Since it is not likely that the Gemini will be revived, we might see the CEV launched by SDV (shuttle derived vehicle) when missions beyond those possible with Delta 4 or Atlas 5 rockets are launched.
One last remark:  Structural integrity and control of shuttle derived rockets could be improved by mounting engines on bottom end of ET rather than on the side.  The engine module would be fitted with a heat shield and parachutes for reentry and reuse.  Aerospike or "plug nozzle" engines might be superior to SSMEs or RS68 engines.  Advanced solid rocket boosters with five segments or liquid boosters might also be used.  There are many possibilities for shuttle derived vehicles.  As exciting as ressurecting the Saturn V would be and upgrading it with new materials and digital technology, the possibilities of the shuttle stack for the development of all sorts of orbital and interplanetary vehicles are probably greater. 
David A. Dietzler, 2007